Spontaneous Remission

An Annotated Bibliography

by Caryle Hirschberg and Brendan O’Regan

In 1993, the Institute of Noetic Sciences published Spontaneous Remission: An Annotated Bibliography. In this work, the authors, Caryle Hirshberg and the late Brendan O’Regan, defined spontaneous remission as “the disappearance, complete or incomplete, of a disease or cancer without medical treatment or treatment that is considered inadequate to produce the resulting disappearance of disease symptoms or tumour.

spontaneous remission



Because there was no standard reference for the field of spontaneous remission before that time, the first task of the Remission Project at IONS was to catalogue the world’s medical literature on the subject. As a result, it assembled the largest database of medically reported cases of spontaneous remission in the world, with more than 3,500 references from more than 800 journals in 20 different languages.

While the authors believe that the phenomenon of remission is relatively rare, the data from their research suggest that it may not be as rare as previously believed. It appears that the impression of rarity is at least partly an artifact of underreporting, but research shows there has been an increase in the number of cases reported in the last few decades.

Spontaneous Remission: An Annotated Bibliography was compiled by Caryle Hirshberg and Brendan O’Reagan. It is organized according to the International Classification of Diseases (ICD-9-CM 9) system.

It is divided into three sections: “Part One: Remission of Cancer” (chapters 1-10), “Part Two: Remission of Diseases Other Than Cancer” (chapters 11-19), and “Part Three,” which contains four appendices and an addendum. Each section contains annotated bibliographic citations—including summaries and in some cases complete text of case reports—and supplemental references.

 All the documents in the bibliography are downloadable in PDF format:

Table of Contents
Introduction Pages 1-52
Chapter 1: pages 53-58
Remission of Neoplasms of Lip, Oral Cavity, and Pharynx
Chapter 2: Pages 59-92 
Remission of Neoplasms of Digestive Organs and Peritoneum
Chapter 3: Pages 93-111
Remission of Neoplasms of Respiratory and Intrathoracic Organs
Chapter 4: Pages 112-142
Remission of Neoplasms of Bone, Connective Tissue, and Soft Tissue
Chapter 5: Pages 143-166
Remission of Neoplasms of the Female Breast
Chapter 6: Pages 167-197
Remission of Neoplasms of the Skin
Chapter 7: Pages 198-219
Remission of Neuroblastoma
Chaper 8: Pages 220-228_
Remission of Neoplasms of Genitourinary Organs
 Chapter 9: Pages 289-309
Remission of Neoplasms of the Eye, Brain, Nervous System, and Endocrine Glands
Chapter 10: Pages 310-348
Remission of Neoplasms of Lymphatic and Hematopoietic Tissue
 Chapter 11: Pages 349-379
Remission of Infectious and Parasitic Diseases
Chapter 12: Pages 380-408
Remission of Endocrine, Nutritional and Metabolic Diseases, and Immunity Disorders
Chapter 13: Pages 409-440
Remission of Diseases of the Circulatory System, Blood, and Blood Forming Organs
Chapter 14: Pages 441-454
Remission of Nervous System, Sense Organs, and Mental Disorders
Chapter 15: Pages 455-460
Remission of Respiratory System Diseases
Chapter 16: Pages 461-475
Remission of Digestive System Diseases
Chapter 17: Pages 476-487
Remission of Genitourinary System, and Pregnancy and Childbirth Related Disorders
Chapter 18: Pages 488-495
Remission of Diseases of the Skin, Subcutaneous Tissue, Musculoskeletal System, and Connective Tissue
Chapter 19: Pages 496-502
Remission of Injury Related Disorders
Appendix One: Pages 503-530
Review Articles
Appendix Two: Pages 531-558
Behavioral Aspects of Remission
Appendix Three: Pages 559-576
Clinical and Experimental Studies
Appendix Four: Pages 577-646
Infection Related Remission
Addendum: Pages 647-674
Index: Pages 675-694
Author Index: Pages 695-703
Journal Index: Pages 704-713

Publication Date: June 1993

Publisher:  Institute of Noetic Sciences

Length: 713 pages